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synta66  (Merck & Co)

 
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    Merck & Co synta66
    Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM <t>Synta66</t> for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.
    Synta66, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/synta66/product/Merck & Co
    Average 90 stars, based on 1 article reviews
    synta66 - by Bioz Stars, 2026-03
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    Images

    1) Product Images from "MASTER-NAADP: a membrane permeable precursor of the Ca 2+ mobilizing second messenger NAADP"

    Article Title: MASTER-NAADP: a membrane permeable precursor of the Ca 2+ mobilizing second messenger NAADP

    Journal: Nature Communications

    doi: 10.1038/s41467-024-52024-y

    Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM Synta66 for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.
    Figure Legend Snippet: Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM Synta66 for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.

    Techniques Used: Incubation, Imaging



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    Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM <t>Synta66</t> for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.
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    Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM <t>Synta66</t> for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.
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    Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM Synta66 for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: MASTER-NAADP: a membrane permeable precursor of the Ca 2+ mobilizing second messenger NAADP

    doi: 10.1038/s41467-024-52024-y

    Figure Lengend Snippet: Global Ca 2+ signaling was analyzed in Jurkat WT T cells ( A ) and Jurkat Hn1l/Jpt2 -/- T cells ( B ), loaded with Fura2-AM. MASTER-NAADP (100 nM), MASTER-NADP (100 nM), or NAADP-AM (100 nM) were added as indicated. Experiments were carried out at 37 °C and SOCE was blocked by pre-incubation of 50 µM Synta66 for 5 min prior to imaging. Number of cells indicated in figure. Aggregated data are mean amplitude per peak ( C ), mean number of Ca 2+ peaks ( D ), percentage of responding cells ( E ), and calculation of the mean responsiveness (number of peaks * amplitude; F presented as mean ± SEM; Jurkat WT MASTER-NAADP, n = 240 cells; Jurkat WT MASTER-NADP, n = 120 cells; Jurkat WT NAADP-AM, n = 91 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NAADP, n = 181 cells; Jurkat Hn1l/Jpt2 -/- MASTER-NADP, n = 113 cells; Jurkat Hn1l/Jpt2 -/- NAADP-AM, n = 110 cells. Nonparametric Kruskal-Wallis test and Dunn’s correction for multiple testing * P < 0.05; **** P < 0.0001. Source data and exact p values are provided as a Source Data file.

    Article Snippet: Additionally, Jurkat T cells were incubated with 50 µM Synta66 (Merck) for 5 min prior to imaging to block SOCE through inhibition of Orai1.

    Techniques: Incubation, Imaging